Benefits of NAD+ Therapy
The fountain of youth! Well, more like the IV drip of youth. NAD+(nicotinamide adenine dinucleotide) is a certain coenzyme found in every living cell of the body but can be depleted by chronic stress and inflammation. It is currently being used as a clever biohack for cognitive rejuvenation, enhancing immunity, drug/alcohol abuse, and longevity.
Many studies have been conducted on the benefits of NAD+ in regards to Alzheimer’s and Parkinson’s disease and other diagnoses involving brain function.1 It has been reported to help activate the brain’s neuron function and protection to clear brain fog, sharpen memory and increase concentration.
NAD+ also helps increase metabolism in the cell and is involved with redox reductions. This helps reduce oxidative stress which contributes to a healthy immune system and reduces internal inflammation.2,3 It helps with muscle strength restoration as well. This may be beneficial for people with obesity, diabetes, chronic fatigue and fibromyalgia or even for athletic achievers.
Adding to its many capabilities, this therapy has been helpful in drug and alcohol abuse recovery.4 Perhaps by contributing to cell and organ repair, restoring neuron function, and reducing inflammation, NAD+ supplementation has been observed to assist in a smooth withdrawal recovery and decreased cravings while rehabilitating from drug and alcohol use.
Lastly, NAD+ is an activator of poly ADP-ribose polymerases (PARPS) , an enzyme in the bloodstream responsible for generating a class of proteins called “sirtuins”. These sirtuins are epigenetic modulators, responsible for epigenetic modification of the genome, activation of a set of genes responsible for slowing aging, and repairing DNA. g. By upregulating the sirtuins, NAD+ is thought to increase longevity and health while reversing effects of aging for a younger, brighter appearance.5
This therapy is an IV treatment for maximum bioavailability that can take about 2-3 hours. Results are best when given in a series. It is known to be an adjunctive treatment for Alzheimer’s, Parkinson’s, Diabetes, mitochondrial dysfunction, multiple sclerosis, fibromyalgia, anxiety/depression, memory/concentration, and feeling of youthfulness.
References
- Minghai Zhou, Gregory Ottenberg, Gian Franco Sferrazza, Christopher Hubbs, Mohammad Fallahi, Gavin Rumbaugh, Alicia F. Brantley, Corinne I. Lasmézas, Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment, Brain, Volume 138, Issue 4, April 2015, Pages 992–1008, https://doi.org/10.1093/brain/awv002
- Lauridsen,C.(2019) From oxidative stress to inflammation: redox balance and immune system, Poultry Science Volume 98, Issue 10, 1 October 2019, Pages 4240-4246 https://doi.org/10.3382/ps/pey407
- Cantó C., Houtkooper R. H., Pirinen E., Youn D. Y., Oosterveer M. H., Cen Y., Fernandez-Marcos P. J., Yamamoto H., Andreux P. A., Cettour-Rose P., Gademann K., Rinsch C., Schoonjans K., Sauve A. A., Auwerx J.(2012) The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity,Cell Metabolism, Volume 15, Issue 6, 6 June 2012, Pages 838-847 https://doi.org/10.1016/j.cmet.2012.04.022
- Pavleka, L.R., Dillarda, J., Rogers L.K.(2020)The role of oxidative stress in toxicities due to drugs of abuse, Current Opinion in Toxicology,Volumes 20–21, April–June 2020, Pages 29-35 https://doi.org/10.1016/j.cotox.2020.04.003
- Koczor C. Q., Saville K. M., .Andrews J. F., Clark J., Fang Q., Li J.,Al-Rahahleh R. Q., Ibrahim M., McClellan S.,Makarov M. V., Migaud M. E., Sobol R. W.(2021) Temporal dynamics of base excision/single-strand break repair protein complex assembly/disassembly are modulated by the PARP/NAD+/SIRT6 axis, Cell Reports, Volume 37, Issue 5, 2 November 2021, 109917 https://doi.org/10.1016/j.celrep.2021.109917